The Ups and Downs of BDNF in Rett Syndrome
نویسندگان
چکیده
Rett syndrome (RTT) is an X-linked postnatal neurodevelopmental disorder, which is primarily caused by mutations in the gene encoding methyl-CpG binding protein 2 (MeCP2). A number of MeCP2 target genes have been identified, including the neurotrophic factor BDNF; however, the functional relevance of these targets has not been established. In this issue of Neuron, Chang et al. provide the first in vivo evidence for a functional interaction between BDNF and MeCP2.
منابع مشابه
Environmental enrichment intervention for Rett syndrome: an individually randomised stepped wedge trial
BACKGROUND Rett syndrome is caused by a pathogenic mutation in the MECP2 gene with major consequences for motor and cognitive development. One of the effects of impaired MECP2 function is reduced production of Brain Derived Neurotrophic Factor (BDNF), a protein required for normal neuronal development. When housed in an enriched environment, MECP2 null mice improved motor abilities and increase...
متن کاملMicroduplication of Xp22.31 and MECP2 Pathogenic Variant in a Girl with Rett Syndrome: A Case Report
Rett syndrome (RS) is a neurodevelopmental infantile disease characterized by an early normal psychomotor development followed by a regression in the acquisition of normal developmental stages. In the majority of cases, it leads to a sporadic mutation in the MECP2 gene, which is located on the X chromosome. However, this syndrome has also been associated with microdeletions, gene translocations...
متن کاملThe Ups and Downs of COVID-19 Epidemics for Orthopedic Community
We started 2020 while facing the largest pandemic of infectious diseases in the last one hundred years and also the most widespread recession in human life. The relatively small size COVID-19 virus has now placed more than half of the world in lockdown and is passing through countries borderless without discrimination. Although our health is primarily at risk due to the disease itself, we canno...
متن کاملPeripheral administration of brain-derived neurotrophic factor to Rett syndrome animal model: A possible approach for the treatment of Rett syndrome
Rett syndrome (RTT) is a postnatal, severe, disabling neurodevelopmental disorder occurring almost exclusively in females and is the second most common cause for genetic mental retardation in girls. In the majority of cases it is caused by mutations in gene (MECP2) encoding methyl-CpG-binding protein 2. Brain-derived neurotrophic factor (BDNF) is a neurotrophic factor playing a major role in ne...
متن کاملInvestigating the Ups and Downs of the Position of the Doctors of the Bukhtishu Dynasty In the Abbasi Caliphate Oeriod (132 to 447 AH)
The physicians of the Bukhtishu dynasty first entered the Abbasi court with the aim of practicing medicine; but soon after, thanks to their medical knowledge and skills, they gained a lot of power and wealth and became involved in power relations at court. Although they were able to gain a high position in the Abbasid court; but their position was constantly unstable, and sometimes they were at...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
- Neuron
دوره 49 شماره
صفحات -
تاریخ انتشار 2006